DRUG AND TOXIN INDUCED HEPATITIS: ACETAMINOPHEN: Acetaminophen is converted by the hepatic cytochrome P 450 drug metabolizing system to a potentially toxic metabolite that is subsequently rendered harmless through conjugation with glutathione. When Tylenol's Impact on Glutathione and Liver Damage Adaptation to acetaminophen exposure elicits major changes in expression and distribution of the hepatic proteome Scientific Reports Downregulation of Glutathione Mediated Detoxification Capacity by Binge Drinking Aggravates Acetaminophen Induced Liver Injury through IRE1 ER Stress Signaling