Early life acetaminophen exposure, glutathione S transferase genes, and development of adolescent asthma in a high risk birth cohort Journal of Allergy and Clinical Immunology Sex differences in glutathione metabolism and acetaminophen toxicity Amazon.com: Talsen Chemicals Reduced L Glutathione Powder DIY Cosmetic Grade Pure Glutathione Organic Powder for Skin, (2 Ounce 56 gram) : Health & Household Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors.