Acetaminophen toxicity Most patients who overdose on acetaminophen will initially be asymptomatic, as clinical symptoms of end organ toxicity do not manifest until 24 48 hours after an acute ingestion. Therefore, to identify a Paracetamol (Acetaminophen) hepatotoxicity and its management. The mechanism of Tylenol toxicity is most likely inducing mitochondrial function by depleting mitochondrial glutathione and occurs biochemically at any dose. Acetaminophen (paracetamol, N acetyl p aminophenol, APAP) is used by 50 million American Tylenol And Glutathione Invigor Medical