Bioderma Sebium Global Cream 30 MLBioderma Sbium Global is the first skin care treatment that acts biologically on the causes and consequences of severe imperfections. The unequalled patented combination of Bakuchiol + patented Fluidactiv, teaches the skin to once again regulate the quality and quantity of its fatty acids in order to produce sebum that is closer to that of healthy skin and to effectively prevent the appearance of spots and blackheads.