How many puffs are in a Vuse pod? Say no to vaping. 10 15 vape puffs are roughly equivalent to one cigarette. We want to encourage and support families to have open and engaging conversations with young people to Vaping vs. Smoking: What's the Nicotine Equivalent? Curious about how vaping compares to smoking? Let's break it down! Disposable Vapes: A typical disposable vape with around 600 puffs can A single vape cartridge can have the nicotine equivalent of 600 cigarettes.