The difference between spermicidal and non spermicidal condoms Do spermicide condoms work? Pros and cons Spermicide and Contraceptive Gel Spermicidal Lube, Gel & Foam Condoms protect against unplanned pregnancy and most sexually transmitted infections, including HIV, gonorrhoea, chlamydia, and syphilis. Use only water or silicone based lubricant with a condom during vaginal and particularly anal sex.